Sorting nexin
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Sorting nexins are a large group of proteins that are localized in the cytoplasm and have the potential for membrane association either through their lipid-binding PX domain (a phospholipid-binding motif) or through protein–protein interactions with membrane-associated protein complexes[1][2] Some members of this family have been shown to facilitate protein sorting.
Family members
In humans, sorting nexins are transcribed from the following genes:
| Genes | Domain Composition | ||||
|---|---|---|---|---|---|
| N-terminus | Mid-1 | Mid-2 | Mid-3 | C-terminus | |
| SNX1, SNX2 | Sorting_nexin_N | – | PX | – | BAR[3] (Vps5) |
| SNX4, SNX7, SNX8, SNX30 | – | – | PX | – | BAR[3] (Vsp5) |
| SNX5, SNX6, SNX32 | – | – | PX | – | BAR[3] |
| SNX9, SNX18, SNX33 | SH3 | – | PX | – | BAR[3] (BAR_3_WASP_bdg)[4] |
| SNX13, SNX14, SNX19, SNX25 | PXA[5] | RGS | PX | – | Nexin_C |
| SNX15 | – | – | PX | – | MIT[6] |
| SNX17, SNX31 | – | – | PX | RA[7] | FERM_M[8] |
| SNX23 | kinesin_motor | SMAD_FHA[9] | PX | – | – |
| SNX26 | – | – | PX | SH3 | RhoGAP |
| SNX27 | PDZ | – | PX | - | FERM_M[8] |
| SNX28 | – | – | PX | SH3 | SH3 |
| SNX3, SNX10, SNX11, SNX12, SNX16, SNX20, SNX21, SNX22, SNX24, SNX29 | – | – | PX | – | – |
Structure
Sorting nexins either consist solely of a PX domain (e.g. SNX3) or have a modular structure made up of the PX and additional domains.
A subgroup of sorting nexins (comprising, in humans, SNX1, SNX2, SNX4, SNX5, SNX6, SNX7, SNX8, SNX9, SNX18, SNX30, SNX32 and SNX33) possess a BAR domain at their C-terminus. (The BAR domain of SNXs 1, 2, 4, 7, 8 and 30 is classified by pfam as 'Vps5 C terminal like'.)
An example of a sorting nexin domain structure can be seen here for SNX1:
- NTD – N-terminal domain
- PX domain
- CTD – C-terminal BAR domain
References
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- ↑ BAR_3_WASP_bdg: WASP-binding domain of Sorting nexin protein, Pfam PF10456
- ↑ PXA: PXA domain, Pfam PF02194
- ↑ MIT: MIT (microtubule interacting and transport) domain, Pfam PF04212
- ↑ RA: Ras association (RalGDS/AF-6) domain, Pfam PF00788
- ↑ a b FERM_M: FERM central domain, Pfam PF00373
- ↑ SMAD_FHA: SMAD/FHA domain, InterPro: IPR008984
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External links
- Template:Replace at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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