PX domain
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The PX domain is a phosphoinositide-binding structural domain involved in targeting of proteins to cell membranes.
This domain was first found in P40phox and p47phox domains of NADPH oxidase (phox stands for phagocytic oxidase).[1][2] It was also identified in many other proteins involved in membrane trafficking, including nexins, Phospholipase D, and phosphoinositide-3-kinases.
The PX domain is structurally conserved in eukaryotes, although amino acid sequences show little similarity.[3] PX domains interact primarily with PtdIns(3)P lipids.[4][5] However some of them bind to phosphatidic acid, PtdIns(3,4)P2, PtdIns(3,5)P2, PtdIns(4,5)P2, and PtdIns(3,4,5)P3. The PX-domain can also interact with other domains and proteins.
Human proteins containing this domain
Sorting nexins contain this domain. Other examples include:
- HS1BP3
- KIF16B (SNX23)
- NCF1; NCF1C; NCF4; NISCH
- PIK3C2A; PIK3C2B; PIK3C2G; PLD1; PLD2; PXK
- RPS6KC1
- SGK3; SH3PXD2A; SNAG1; SNX9
References
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