Rs6314
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In genetics, rs6314, also called His452Tyr or H452Y, is a gene variation, a single nucleotide polymorphism (SNP), in the HTR2A gene that codes for the 5-HT2A receptor. The SNP is located in exon 3 of the gene and the change between C and T results in a change between histidine (His) and tyrosine (Tyr) at the 452nd amino acid, i.e., it is a missense substitution.[1]
As 5-HT2A is a neuroreceptor the SNP has been investigated in connection with neuropsychiatric disorders[2] and other brain-related variables. A 2003 study looked at memory performance and found that His/His subjects performed better.[3] Another study reported that the SNP had an effect on the memory performance in young adults.[4] This has been replicated by another group.[5]
The His452Tyr variant may influence cell signaling.[6]
rs6311, rs6313 and rs7997012 are other investigated SNPs in the HTR2A gene.
References
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