Rs7997012
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In genetics, rs7997012 is a gene variation—a single nucleotide polymorphism (SNP)—in intron 2 of the human HTR2A gene that codes for the 5-HT2A receptor. The SNP varies between adenine (A) and guanine (G) DNA bases with the G-allele being most frequent.[1] A research study found it to be related to antidepressant treatment.[2] The research group reported that a polymorphism (rs1954787) on another gene, the GRIK4, has also shown a treatment-response-association in this kind of treatment.[3] In a Japanese study rs7997012 was not associated with either major depressive disorder or bipolar disorder.[4]
Rs6311, rs6313 and His452Tyr (rs6314) are other SNPs in the HTR2A gene. There are many more, even in intron 2 alone.[5]
References
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