NFKB1

Template:Short description Template:Infobox gene Nuclear factor NF-kappa-B p105 subunit is a protein that in humans is encoded by the NFKB1 gene.

This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappaB (NF-κB) protein complex. NF-κB is a transcription factor that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NF-κB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions; over 200 known genes are targets of NF-κB in various cell types, under specific conditions. Inappropriate activation of NF-κB has been associated with a number of inflammatory diseases while persistent inhibition of NF-κB leads to inappropriate immune cell development or delayed cell growth.

Interactions

NFKB1 has been shown to interact with:

• BCL3,
• C22orf25,
• HDAC1,
• HMGA2
• IKK2,
• ITGB3BP,
• IκBα,
• LYL1,
• MAP3K7IP2,
• MAP3K8,
• MEN1,
• NFKB2,
• NFKBIE,
• NOTCH1,
• Nuclear receptor coactivator 1,
• RELA,
• RELB,
• STAT3,
• STAT6, and
• TSC22D3.

External links

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• Template:FactorBook

Template:PDB Gallery Template:Transcription factors This article incorporates text from the United States National Library of Medicine, which is in the public domain.