HDAC1
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Template:Short description Template:Cs1 config Template:Infobox gene Histone deacetylase 1 (HDAC1) is an enzyme that in humans is encoded by the HDAC1 gene.[1]
Function
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2 MTA2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.[2]
Interactions
HDAC1 has been shown to interact with:
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- Androgen receptor,[3]
- BCL6,[4][5]
- BTG2,[6][7]
- BUB1B,[8]
- BUB1,[8]
- BUB3,[8]
- CBFA2T3,[9][10]
- CDC20,[8]
- CDH1,[8]
- CHD3,[11][12]
- CHD4,[11][13][14]
- COUP-TFII,[15]
- CTBP1,[16][17][18]
- DDX17,[19]
- DDX5,[19]
- DNMT3A,[20]
- DNMT3L,[21][22]
- Death-associated protein 6,[23]
- EED,[24]
- EVI1,[25][26]
- EZH2,[24]
- FKBP3,[27]
- GATA1,[28]
- HMG20B,[29]
- HSPA4,[30]
- HUS1,[31]
- Histone deacetylase 2,[11][13][24][29][30][32][33][34][35][36][37][38][39]
- Homeobox protein TGIF1,[16][40]
- Host cell factor C1,[41]
- IFRD1,[42]
- IKZF1,[43][44]
- ING1,[12][45]
- MBD3,[37][46][47]
- MIER1,[48]
- MLL,[49]
- MTA1,[13][50]
- MTA2,[13][37][51][52]
- Mad1,[8]
- Mdm2,[53]
- Methyl-CpG-binding domain protein 2,[37][54][55]
- Mothers against decapentaplegic homolog 2,[56]
- MyoD,[57][58]
- NFKB1,[59]
- Nuclear receptor co-repressor 2,[32][60]
- P21,[61]
- PCNA,[62]
- PHF21A,[29][63]
- Prohibitin,[64][65]
- Promyelocytic leukemia protein,[66][67]
- RAD9A,[31]
- RBBP4,[13][14][37][38][39][51][54][68][69][70][71]
- RBBP7,[13][37][39][54]
- RCOR1,[29][51]
- RELA,[36][59][72]
- RFC1,[73]
- Retinoblastoma protein,[57][65][74][75][76][77][78]
- Retinoblastoma-like protein 1,[74][75]
- Retinoblastoma-like protein 2,[74][79]
- SAP30,[12][37][80][81][82][83]
- SATB1,[52]
- SIN3A,[11][12][13][14][37][38][51][52][68][69][84][85][86][87]
- SIN3B,[37][43]
- SPEN,[88]
- SUDS3,[84][89]
- SUV39H1,[90]
- Sp1 transcription factor,[69][91][92][93]
- TOP2A,[94][95]
- TOP2B,[94][95] and
- Zinc finger and BTB domain-containing protein 16.[4][96][97]
See also
References
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Further reading
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External links
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