HDAC1

Template:Short description Template:Cs1 config Template:Infobox gene Histone deacetylase 1 (HDAC1) is an enzyme that in humans is encoded by the HDAC1 gene.

Function

Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2 MTA2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.

Interactions

HDAC1 has been shown to interact with:

• Androgen receptor,
• BCL6,
• BTG2,
• BUB1B,
• BUB1,
• BUB3,
• CBFA2T3,
• CDC20,
• CDH1,
• CHD3,
• CHD4,
• COUP-TFII,
• CTBP1,
• DDX17,
• DDX5,
• DNMT3A,
• DNMT3L,
• Death-associated protein 6,
• EED,
• EVI1,
• EZH2,
• FKBP3,
• GATA1,
• HMG20B,
• HSPA4,
• HUS1,
• Histone deacetylase 2,
• Homeobox protein TGIF1,
• Host cell factor C1,
• IFRD1,
• IKZF1,
• ING1,
• MBD3,
• MIER1,
• MLL,
• MTA1,
• MTA2,
• Mad1,
• Mdm2,
• Methyl-CpG-binding domain protein 2,
• Mothers against decapentaplegic homolog 2,
• MyoD,
• NFKB1,
• Nuclear receptor co-repressor 2,
• P21,
• PCNA,
• PHF21A,
• Prohibitin,
• Promyelocytic leukemia protein,
• RAD9A,
• RBBP4,
• RBBP7,
• RCOR1,
• RELA,
• RFC1,
• Retinoblastoma protein,
• Retinoblastoma-like protein 1,
• Retinoblastoma-like protein 2,
• SAP30,
• SATB1,
• SIN3A,
• SIN3B,
• SPEN,
• SUDS3,
• SUV39H1,
• Sp1 transcription factor,
• TOP2A,
• TOP2B, and
• Zinc finger and BTB domain-containing protein 16.

See also

• Histone deacetylase
• Histone deacetylase inhibitor

External links

• Template:Replace at the U.S. National Library of Medicine Medical Subject Headings (MeSH)