MAP3K7IP2

Template:Cs1 config Template:Short description Template:Infobox gene Mitogen-activated protein kinase kinase kinase 7-interacting protein 2 is an enzyme that in humans is encoded by the MAP3K7IP2 gene.

The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKL through the activation of the receptor activator of NF-kappB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Mutations in MAP3K7IP2 have been associated with human congenital heart defects.

Interactions

MAP3K7IP2 has been shown to interact with:

• HDAC3,
• TAB1,
• MAP3K7IP3,
• MAP3K7,
• NFKB1,
• NUMBL,
• Nuclear receptor co-repressor 1,
• TRAF2, and
• TRAF6.

External links

• Template:PDBe-KB2
• Template:PDBe-KB2

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