MAP3K7IP3
Template:Short description Template:Infobox gene Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 is an enzyme that in humans is encoded by the MAP3K7IP3 gene.[1][2][3]
Function
The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[3]
Interactions
MAP3K7IP3 has been shown to interact with MAP3K7IP2,[1] TAB1[2] and MAP3K7.[1][2]
References
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Further reading
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