HLA-A74
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HLA-A74 (A74) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α74 subset of HLA-A α-chains. For A74, the alpha "A" chain are encoded by the HLA-A<templatestyles src="Template:Color/styles.css" />*74 allele group and the β-chain are encoded by B2M locus.[1] A74 and A<templatestyles src="Template:Color/styles.css" />*74 are almost synonymous in meaning. A74 is a split antigen of the broad antigen serotype A19. A74 is a sister serotype of A29, A30, A31, A32, and A33. Script error: No such module "labelled list hatnote". A74 is more common in Subsaharan Africa. A74 is a rare HLA-A allele group.
Serotype
| A*74 | A74 | A<templatestyles src="Template:Color/styles.css" />19 | Sample |
| allele | % | % | size (N) |
| *7401 | 40 | <templatestyles src="Template:Color/styles.css" />11 | 119 |
| *7403 | 17 | 0 | 29 |
A74 has a poor serotyping rate.
Disease associations
A significant association has been found between A74 and nasal polyposis.[3]
Allele distribution
Template:AlleleFreq Template:AlleleFreq
Sources
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References
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- ↑ Script error: No such module "Citation/CS1".
- ↑ Allele Query Form IMGT/HLA - European Bioinformatics Institute
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