HLA-A32
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HLA-A32 (A32) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α32 subset of HLA-A α-chains. For A32, the alpha "A" chain are encoded by the HLA-A<templatestyles src="Template:Color/styles.css" />*32 allele group and the β-chain are encoded by B2M locus.[1] This group currently is dominated by A*3201. A32 and A<templatestyles src="Template:Color/styles.css" />*32 are almost synonymous in meaning. A32 is a split antigen of the broad antigen serotype A19. A32 is a sister serotype of A29, A30, A31, A33, and A74. Script error: No such module "labelled list hatnote".
Serotype
| A*32 | A32 | Sample |
| allele | % | size (N) |
| *3201 | 94 | 3441 |
A32 Serotyping efficiency for the predominant allele is good. There are 16 known alleles that result in 15 isoforms of HLA-A32. One isoform may be poorly expressed.[3].
Distribution
A32 is most common around the Persian Gulf and the Mediterranean Basin. It has a consistent presence in Europe. The A32 frequencies in the more isolated (genetically) peoples of Europe suggests that the A32 rise in the Mediterranean may only be partially attributable to recent migrations from the middle eastern region. There is a node in southern Europe around the Ionian Sea in which specific, European, A32-haplotypes are elevated.
Haplotypes
| freq | ||
| ref. | Population | (%) |
| A32-B7 (A*3201:B*0702) | ||
| Albanian | 2.2 | |
| Cuban | 1.9 | |
| [4] | Natal Zulu (S. Africa) | 1.0 |
| Cretan | 0.7 | |
| Cretan | 0.2 | |
| A32-B8 (A*3201:B*0801) | ||
| N. Portugal | 2.2 | |
| Oman | 1.8 | |
| A32-B14 (A*3201:B*14) | ||
| !kung | 1.9 | |
| Tunis | 1.8 | |
| Natal Zulu (S. Africa) | 1.0 | |
| Portugal | 1.1 | |
| Irish | 0.7 | |
| Italian | 0.6 | |
| A32-B27 (A*3201:B27) | ||
| Gypsy(Spanish) | 6.0 | |
| E Black Sea (Turkey) | 2.3 | |
| German | 0.3 | |
| A32-B35 (A*3201:C*0401:B*3501) | ||
| Greek | 3.5 | |
| UA Emirates | 2.8 | |
| Sardinian | 2.6 | |
| Brahui (Pakistan) | 2.5 | |
| Tunisia | 1.8 | |
| Armenian | 1.7 | |
| Italian | 1.5 | |
| Oman | 1.3 | |
| Portugal | 1.1 | |
| German | 0.3 | |
| A32-B61(40) (A*3201:B*40) | ||
| Tunis | 1.2 | |
| Greek | 1.2 | |
| French | 0.6 | |
| German | 0.4 | |
| A32-B44 (A*3201:B*4402) | ||
| Austrian | 2.4 | |
| Belgium | 2.0 | |
| Albanian | 1.8 | |
| S. Portugal | 1.0 | |
| Irish | 0.7 | |
| German | 0.6 | |
| Dutch | 0.6 | |
| Senegal | 0.5 | |
| Italian | 0.4 | |
| A32-B51 (A*3201:C*1201:B*5101) | ||
| Bulgarian | 1.8 | |
| German | 0.3 | |
| (A*3201:C*1502:B*5101) | ||
| Oman | 5.0 | |
| Baloch (Pakistan) | 3.2 | |
| Kalash | 2.9 | |
| UA Emirates | 1.9 | |
| Baloch (Iran) | 1.1 | |
| (A*3201:C*1401:B*5101) | ||
| Parsis (Karachi) | 4.9 | |
| Kalash | 2.9 | |
A common A32 haplotype A*3201-B*5101 can be found in Oman, United Arab Emirates, SE Iran, Bulgaria, and Portugal. A second, A*3201-B*3501 can be in the Omani, UAE, and Portugal.
References
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- ↑ Allele Query Form IMGT/HLA - European Bioinformatics Institute
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- ↑ B*0705
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