HLA-A31
Template:Short description Script error: No such module "Infobox".Template:Template other
HLA-A31 (A31) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α31 subset of HLA-A α-chains. For A31, the alpha "A" chain are encoded by the HLA-A<templatestyles src="Template:Color/styles.css" />*31 allele group and the β-chain are encoded by B2M locus.[1] This group currently is dominated by A*3101. A31 and A<templatestyles src="Template:Color/styles.css" />*31 are almost synonymous in meaning. A31 is a split antigen of the broad antigen serotype A19. A31 is a sister serotype of A29, A30, A32, A33, and A74. Script error: No such module "labelled list hatnote". A31 is more common in South and Central America.
Serotype
| A*31 | A31 | A<templatestyles src="Template:Color/styles.css" />19 | A<templatestyles src="Template:Color/styles.css" />30 | Sample |
| allele | % | % | % | size (N) |
| *3101 | 90 | <templatestyles src="Template:Color/styles.css" />1 | <templatestyles src="Template:Color/styles.css" />3 | 3517 |
| *3102 | 100 | 0 | 0 | 11 |
There is substantive false reaction of A30 with A*3101, otherwise serological identification is good.
Distribution
Haplotypes
| freq | ||
| ref. | Population | (%) |
| A31-B35 (A*310102:Cw*0401:B*3501) | ||
| Lakota Sioux (USA) | 4.1 | |
| Indig American (USA) | 3.7 | |
| Mestizo (Guad. Mexico) | 1.5[3] | |
| Tibetan | 1.1 | |
| Jews (England) | 1.3 | |
| Tibetan | 1.1 | |
| Italian | 0.6 | |
| Japanese | 0.5 | |
| French | 0.5 | |
| Choushan (China) | 0.4 | |
| German | 0.3 | |
| A31-B39 (A*310102:Cw*0701:B*3901) | ||
| Mixtec (Oax. Mexico) | 10.0 | |
| Lakota Sioux (USA) | 1.6 | |
| Japanese | 0.3 | |
| German | 0.1 | |
| A31-B48 (A*310102:B*4801) | ||
| Orochon (Russia) | 6.0 | |
| Maya (Guatemala) | 3.5 | |
| Buriat | 3.4 | |
| Japanese | 0.3 | |
| A31-B51 (A*310102:B*5101) | ||
| Ainu (Hokkaido Japan) | 8.9 | |
| Indig. Brazil | 5.8 | |
| Orochon (Russia) | 5.3 | |
| Indig American (USA) | 4.3 | |
| Tibetan | 3.3 | |
| Inner Mongolian | 3.0 | |
| Japanese | 3.0 | |
| Portuguese | 1.6 | |
| Korean | 1.2 | |
| Italian | 0.9 | |
| French | 0.5 | |
| German | 0.3 | |
| Choushan (China) | 0.2 | |
| (A*310102:B*5102) | ||
| Tarahumura (Mexico) | 5.7 | |
| Vietnamese | 1.0 | |
| A31-B60 (A*310102:Cw*0304:B*4001) | ||
| Lusaka (Zambia) | 2.3 | |
| Yakuts (Russia) | 2.0 | |
| Irish | 0.7 | |
| Choushan (China) | 0.7 | |
| Japan | 0.6 | |
| Dutch | 0.6 | |
| German | 0.4 | |
| A31-B62 (A*310102:B*1501) | ||
| Nivkhi (Sakalin, Russia) | 12.5 | |
| Yakut(Russia) | 5.5 | |
| Indig. Brazil | 4.1 | |
| Manchu | 1.1 | |
| Japan | 0.4 | |
| German | 0.2 | |
| Choushan (China) | 0.2 | |
Examination of A31 haplotypes reveals a probable connection across northern Eurasia during the prehistoric period. Frequencies of the more 'tale-tell' haplotypes (A31-B60, B61, and B62) fall from NE to SW Europe. Other haplotypes appears to have spread from the Middle East (A31-B51 and A31-B35).
References
<templatestyles src="Reflist/styles.css" />
- ↑ Script error: No such module "Citation/CS1".
- ↑ Allele Query Form IMGT/HLA - European Bioinformatics Institute
- ↑ B*3512
Script error: No such module "Check for unknown parameters".
Script error: No such module "Navbox".