Class C GPCR
Template:Short description Template:Pfam box
The class C G-protein-coupled receptors (InterPro: IPR000337) are a class of G-protein coupled receptors that include the metabotropic glutamate receptors (InterPro: IPR000162) and several additional receptors.[1]
Structurally they are composed of four elements; an N-terminal signal sequence; a large hydrophilic extracellular agonist-binding region containing several conserved cysteine residues which could be involved in disulphide bonds; a shorter region containing seven transmembrane domains; and a C-terminal cytoplasmic domain of variable length.[1] This protein family includes metabotropic glutamate receptors, the extracellular calcium-sensing receptors, the gamma-amino-butyric acid (GABA) type B receptors, and the vomeronasal type-2 receptors.
Subfamilies
GABAB receptors
- GABAB receptor (gamma-aminobutyric acid) InterPro: IPR002455
Metabotropic glutamate receptors
RAIG
Taste receptors
Orphan
Other
- Bride of sevenless protein InterPro: IPR002956
- Vomeronasal receptor, type 2 InterPro: IPR004073
References
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