GPRC5D
Template:Short description Template:Cs1 config Template:Infobox gene G-protein coupled receptor family C group 5 member D is a protein that in humans is encoded by the GPRC5D gene.[1] GPRC5D is a class C orphan G protein-coupled receptor predominantly expressed in multiple myeloma cells and hard keratinized tissues, with low expression in normal human tissues, rendering it an appealing target for multiple myeloma cells.[2][3][4]
Structure
Structural analysis of the complex between GPRC5D and talquetamab, a bispecific antibody for the treatment of multiple myeloma, has revealed that GPRC5D exists as a dimer. GPRC5D forms a symmetric dimer via TM4 and TM4/TM5 interactions. The study further demonstrated that only one talquetamab molecule can bind to the dimeric form of GPRC5D. Talquetamab Fab recognizes ECLs and TM3/5/7 of one GPRC5D protomer via six CDRs. [5]
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Function
The protein encoded by this gene is a member of the G protein-coupled receptor family; however, the specific function of this gene has not yet been determined.[1]
See also
References
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Further reading
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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