GPRC5A
Template:Cs1 config Template:Short description Template:Infobox gene Retinoic acid-induced protein 3 is a protein that in humans is encoded by the GPRC5A gene.[1][2] This gene and its encoded mRNA was first identified as a phorbol ester-induced gene, and named Phorbol Ester Induced Gen 1 (PEIG-1);[3] two years later it was rediscovered as a retinoic acid-inducible gene, and named Retinoic Acid-Inducible Gene 1 (RAIG1).[1] Its encoded protein was later named Retinoic acid-induced protein 3.
Function
This gene encodes a member of the type 3 G protein-coupled receptor family, characterized by the signature 7-transmembrane domain motif. The encoded protein may be involved in interaction between retinoic acid and G protein signalling pathways. Retinoic acid plays a critical role in development, cellular growth, and differentiation. This gene may play a role in embryonic development and epithelial cell differentiation.[2] Tryptamine and other indole related chemicals produced by gut microflora bind and activate the receptor.[4]
Post transcriptional regulation
GPRC5A is one of only a handful of genes known in the literature that are post-transcriptionally controlled by miRNAs through their 5'UTR.[5]
Clinical significance
GPRC5A is dysregulated in many human cancers and in other diseases.[6]
See also
References
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Further reading
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External links
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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