TRPC5
Template:Cs1 config Template:Short description Template:Infobox gene Short transient receptor potential channel 5 (TrpC5) also known as transient receptor protein 5 (TRP-5) is a protein that in humans is encoded by the TRPC5 gene.[1][2][3] TrpC5 is subtype of the TRPC family of mammalian transient receptor potential ion channels.
Function
TrpC5 is one of the seven mammalian TRPC (transient receptor potential canonical) proteins. TrpC5 is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. The protein is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. It also interacts with multiple proteins including calmodulin, CABP1, enkurin, Na+–H+ exchange regulatory factor (NHERF), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1).[1]
TRPC4 and TRPC5 have been implicated in the mechanism of mercury toxicity[4] and neurological behavior.[5] It was established in 2021 that TRPC5 is a component of the dental cold sensing system.[6]
Activation
Homomultimeric TRPC5 and heteromultimeric TRPC5-TRPC1 channels are activated by extracellular reduced thioredoxin.[7] This channel has also been found to be involved in the action of anaesthetics such as chloroform, halothane and propofol.[8]
Interactions
TRPC5 has been shown to interact with STMN3,[9] TRPC1,[10][11] and TRPC4.[11]
See also
References
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Further reading
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External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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