TRPC4
Template:Short description Template:Use dmy dates Template:Infobox gene The short transient receptor potential channel 4 (TrpC4), also known as Trp-related protein 4, is a protein that in humans is encoded by the TRPC4 gene.[1][2]
Function
TrpC4 is a member of the transient receptor potential cation channels. This protein forms a non-selective calcium-permeable cation channel that is activated by Gαi-coupled receptors, Gαq-coupled receptors and tyrosine kinases, and plays a role in multiple processes including endothelial permeability, vasodilation, neurotransmitter release and cell proliferation.[3]
Tissue distribution
The nonselective cation channel TrpC4 has been shown to be present in high abundance in the cortico-limbic regions of the brain.[4] In addition, TRPC4 mRNA is present in midbrain dopaminergic neurons in the ventral tegmental area and the substantia nigra.[5]
Roles
Deletion of the trpc4 gene decreases levels of sociability in a social exploration task. These results suggest that TRPC4 may play a role in regulating social anxiety in a number of different disorders.[6] However deletion of the trpc4 gene had no impact on basic or complex strategic learning.[7] Given that the trpc4 gene is expressed in a select population of midbrain dopamine neurons, it has been proposed that it may have an important role in dopamine related processes including addiction and attention.[5]
Clinical significance
Single nucleotide polymorphisms in this gene may be associated with generalized epilepsy with photosensitivity.[8]
Interactions
TRPC4 has been shown to interact with ITPR1,[9][10] TRPC1,[11][12] and TRPC5.[12]
See also
References
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Further reading
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External links
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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