Zinc finger and BTB domain-containing protein 16
Template:Short description Template:Infobox gene Zinc finger and BTB domain-containing protein 16 is a protein that in humans is encoded by the ZBTB16 gene.
Function
This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL)[1] and physiological roles have been identified in mouse Natural Killer T cells[2][3] and gamma-delta T cells.[4] Alternate transcriptional splice variants have been characterized in human.[5][6]
Interactions
Zinc finger and BTB domain-containing protein 16 has been shown to interact with:
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- Angiotensin II receptor type 1,[7]
- BCL6,[8]
- BMI1,[9]
- Calcitriol receptor,[10][11]
- FHL2,[12]
- GATA1,[13]
- GATA2,[14]
- HDAC1,[15][16][17]
- HDAC4,[15][18]
- HDAC5,[15][18]
- HDAC6,[15]
- Heparin-binding EGF-like growth factor,[19][20]
- Nuclear receptor co-repressor 2,[17][21][22]
- Promyelocytic leukemia protein[23]
- RUNX1T1,[24][25]
- Retinoic acid receptor alpha,[26]
- SIN3A,[10][16][17]
- SIN3B,[16] and
- ZBTB32.[27]
See also
References
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Further reading
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External links
- Template:Replace at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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