RUNX1T1

Template:Short description Template:Infobox gene Protein CBFA2T1 is a protein that in humans is encoded by the RUNX1T1 gene.

Function

The protein encoded by this gene is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Several transcript variants encoding multiple isoforms have been found for this gene.

Interactions

RUNX1T1 has been shown to interact with:

• CBFA2T2,
• CBFA2T3,
• Calcitriol receptor
• GFI1,
• Nuclear receptor co-repressor 1,
• Nuclear receptor co-repressor 2,
• PRKAR2A, and
• Zinc finger and BTB domain-containing protein 16.