MCM7
Template:Short description Template:Infobox gene DNA replication licensing factor MCM7 is a protein that in humans is encoded by the MCM7 gene.[1]
Function
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre-RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumor suppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.[2]
Interactions
MCM7 has been shown to interact with:
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- CDC45-related protein[3][4]
- CDC6,[3][5]
- Cell division cycle 7-related protein kinase,[3]
- DBF4,[3]
- MCM2,[3][6][7][8][9]
- MCM3,[3][5][6][10]
- MCM4,[6][7][8][11]
- MCM5,[3][6][12]
- MCM6,[3][6][7][8]
- MNAT1,[13]
- ORC1L,[3]
- ORC2L,[3]
- ORC3L,[3]
- ORC5L,[3]
- Replication protein A1,[3]
- Retinoblastoma protein,[14] and
- UBE3A.[15]
See also
References
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Further reading
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