HLA-DR52
| Illustration of an HLA-DR (Human MHC class II) antigen receptor with bound antigen | ||
major histocompatibility complex, class II, DR53
| ||
| Haplotypes groups | DRA*01:DRB3*01 DRA*01:DRB3*02 DRA*01:DRB3*03 | |
| Structure (See HLA-DR) | ||
| Identifiers | alpha *01:01
| |
| Symbol(s) | HLA-DRAScript error: No such module "Unsubst". | |
| EBI-HLA | DRA*01:01 | |
| Identifiers | beta 3 *01 *02 *03
| |
| Symbol(s) | HLA-DRB3Script error: No such module "Unsubst". | |
| EBI-HLA | DRB3*01 | |
| EBI-HLA | DRB3*02 | |
| EBI-HLA | DRB3*03 Template:Webarchive | |
| Shared data | ||
| Locus | chr.6 6p21.31 | |
HLA-DR52 is an HLA-DR serotype that recognizes gene products of HLA-DRB3 locus. Three allele groups can produce 35 isoforms.
DRB3, DRB4, and DRB5 are minor DR beta-encoding loci, and they have been recognized as having distinct evolution,[1] having diverged from DRB1 around 4 million years ago.[2]
The DRB3 locus is only apparent in a small subset of DR haplotypes, and most individuals lack DRB3.
Alleles
| DRB3* | DR52 | ? | Sample |
| allele | % | % | size (N) |
| 01:01 | 95 | 62 | |
| 01:02 | 99 | 1 | |
| 02:01 | 99 | 2 | |
| 02:02 | 95 | 100 | |
| 02:03 | 95 | 1 | |
| 03:01 | 95 | 36 |
Associated diseases
DR52 serotype is positively associated with systemic sclerosis,[4] inflammatory myopathies,[5] inclusion body myositis,[6]
DRB3*01 is positively associated with sarcoidosis,[7] Grave's Disease,[8][9] pulmonary sarcoidosis,[10]
DRB3*01:01:DRB1*03:01 is linked to Lofgren's syndrome[11]
DRB3*02:02 is also linked to Grave's disease,[9] serum IgG antibodies to Chlamydia pneumoniae with essential hypertension,[12] acute necrotizing encephalopathy[13]
DRB3*03:01 is weakly associated with anticardiolipin antibodies in SLE[14]
DRB3*03:01:DRB1*13:02 may be associated with Crohn's disease[15]
DRB1 linkage
HLA-DRB3 is linked to these HLA-DR serotypes and DRB1 allele groups:
HLA-DR3 - DRB1*03
HLA-DR5 -
HLA-DR6 -
HLA-DR52 - Sjögren syndrome
References
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