HLA-DR14
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| Illustration of an HLA-DR (Human MHC class II) antigen receptor with bound antigen | |
major histocompatibility complex, class II, DR14
| |
| Haplotypes groups | DRA*01:DRB1*1401 DRA*01:DRB1*1402 DRA*01:DRB1*1403 DRA*01:DRB1*1404 .... |
| Structure (See HLA-DR) | |
| Identifiers | alpha *0101
|
| Symbol(s) | HLA-DRAScript error: No such module "Unsubst". |
| EBI-HLA | DRA*0101 |
| Identifiers | beta 1 *1401 to *1408 *1410
|
| Symbol(s) | HLA-DRB1Script error: No such module "Unsubst". |
| EBI-HLA | DRB1*1401 Template:Webarchive |
| EBI-HLA | DRB1*1402 |
| EBI-HLA | DRB1*1403 |
| EBI-HLA | DRB1*1404 |
| EBI-HLA | DRB1*1405 Template:Webarchive |
| EBI-HLA | DRB1*1406 |
| Shared data | |
| Locus | chr.6 6p21.31 |
HLA-DR14(DR14) is a HLA-DR serotype that recognizes the DRB1*1401 to *1408, *1410 to *1418, and other *14 gene products. DR14 serotype is a split antigen of the older HLA-DR6 serotype group which also contains the similar HLA-DR13 antigens.
Alleles
| DRB1* | DR14 | DR6 | DR13 | Sample |
| allele | % | % | % | size (N) |
| 1401 | 74 | 14 | 3 | 1942 |
| 1402 | 61 | 13 | 9 | 204 |
| 1403 | 72 | 12 | 2 | 37 |
| 1404 | 79 | 8 | 80[2] | |
| 1405 | 86 | 10 | 58 | |
| 1406 | 37 | 15 | 22 | 117 |
| 1407 | 90 | 10 | ||
| 1408 | 25 | 4 | ||
| 1410 | >75 | 4 |
Serotypes are unknown the following alleles: DRB1**1409, *1419 to *1462
Disease associations
DRB1*1402: juvenile rheumatoid arthritis,[4] increased longevity in Okinawans.
Extended linkage
DR*14:DQ5 haplotype: increased risk for non-AChR autoantibodies in myasthenia gravis.[5]
Genetic Linkage
DR14 Haplotypes
| |||
| DRA | DRB1 | DRB3 | |
|---|---|---|---|
| DR14(6)-DR52 | *0101 | *1401 | *0201 |
| *0101 | *1402 | *0201 | |
| *0101 | *1403 | *0101 | |
| DQA1 | DQB1 | DRB1 | |
| DR14-DQ5(5.3, 1) | *0104 | *0503 | *1401 |
| HLA-A | HLA-B | DRB1 | |
| A11-B35-DR14(6) | *1101 | *3501 | *1401 |
| A2-B51(5)-DR14(6) | *0201 | *5101 | *1401 |
HLA-DR13 is genetically linked to HLA-DR52[6] and HLA-DQ5 (HLA-DQ1) serotypes.
References
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