HLA-B52

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Template:Short description Template:Further2

Illustration of HLA-B with peptide in the binding pocket.
B*5101-β2MG with bound peptide Template:PDB2
major histocompatibility complex (human), class I, B52
Alleles B*5201, 5202, 5203, . . .
Structure (See HLA-B)
Shared data
Locus chr.6 6p21.31

HLA-B52 (B52) is an HLA-B serotype. The serotype identifies the more common HLA-B*52 gene products.[1]

B52 is a split antigen of the broad antigen B5, and is a sister type of B51. B*5201 likely formed as a result of a gene conversion event between another HLA-B allele and HLA-B*5101.[2] There are a number of alleles within the B*52 allele group.[3]

Serotype

Serotypes B52, B5, B51, and B53 recognition of HLA B*5201 gene product[4]
B*52 B52 B5 B51 B53 Sample
allele % % % % size (N)
Template:Asterisk5201 84 2 7 1 2823
Alleles link-out to IMGT/HLA Databease at EBI
HLA *5201 frequencies
freq
ref. Population (%)
[5] China Yunnan Lisu 21.7
[5] China Yunnan Nu 18.6
[5] Bulgaria Gipsy 18.2
[5] Venezuela Sierra de Perija Yucpa 12.8
[5] India Andhra Pradesh Golla 12.0
[5] Japan Central 10.7
[5] Japan 10.4
[5] Georgia Tbilisi Kurds 10.3
[5] Mali Bandiagara 8.3
[5] South Africa Natal Tamil 8.2
[5] Israel Ashk. and Non-Ashk. Jews 7.3
[5] India North Hindus 6.7
[5] China Beijing 6.1
[5] India New Delhi 6.1
[5] India Mumbai Marathas 5.6
[5] Tunisia Ghannouch 5.5
[5] Thailand pop3 5.1
[5] India West Coast Parsis 5.0
[5] India North Delhi 4.9
[5] Mexico Mestizos 4.9
[5] Argentina Toba Rosario 4.7
[5] Mexico Zaptotec Oaxaca 4.5
[5] USA Hispanic 4.5
[5] China Qinghai Hui 4.1
[5] China Inner Mongolia 3.9
[5] China North Han 3.8
[5] Oman 3.8
[5] Senegal Niokholo Mandenka 3.7
[5] Bulgaria 3.6
[5] Thailand 3.5
[5] Ivory Coast Akan Adiopodoume 3.4
[5] Venezuela Perja Mountain Bari 3.4
[5] Italy North pop 1 3.3
[5] Sudanese 3.3
[5] Romanian 3.2
[5] Singapore Riau Malay 3.0
[5] Autonomous Region Tibetans 2.8
[5] Russia Tuva pop 2 2.8
[5] South Korea pop 3 2.8
[5] Iran Baloch 2.5
[5] Tunisia 2.5
[5] Jordan Amman 2.4
[5] USA Hawaii Okinawa 2.4
[5] Singapore Javanese Indonesians 2.0
[5] Spain Eastern Andalusia 1.8
[5] Macedonia pop 4 1.6
[5] Uganda Kampala 1.6
[5] Belgium 1.5
[5] Mexico Guadalajara Mestizos pop2 1.5
[5] Singapore Thai 1.5
[5] Brazil 1.4
[5] China Yunnan Lisu 1.4
[5] Azores Santa Maria and Sao Miguel 1.3
[5] France South East 1.2
[5] Italy North Pavia 1.2
[5] Saudi Arabia Guraiat and Hail 1.2
[5] Mexico Chihuahua State Tarahumara 1.1
[5] Tunisia Tunis 1.1
[5] Israel Arab Druse 1.0
[5] Japan Ainu Hokkaido 1.0
[5] Portugal Centre 1.0
[5] Singapore Chinese 1.0
[5] Taiwan Minnan pop 1 1.0
[5] USA Caucasian 1.0
[5] Azores Central Islands 0.9
[5] China South Han 0.9
[5] Macedonia pop 4 0.7
[5] Morocco Nador Metalsa Class I 0.7
[5] Georgia Svaneti Svans 0.6
[5] Ireland South 0.6
[5] Italy Bergamo 0.6

Alleles

There are 18 alleles, with 14 amino acid sequence variants in B52. Of these only 9 are frequent enough to have been reliably serotyped. B*5201 is the most common, but others have a large regional abundance.

Disease

In ulcerative colitis

HLA-B52 appears to have the strongest linkage to ulcerative colitis in Japan.[6][7] This form of disease is frequently found with Takayasu's arteritis.[8][9]

In Takayasu's arteritis

Takayasu's arteritis appears to have an independent link to B52 associated disease.[10][11] The association with B*5201 increases risk of pulmonary infarction, ischemic heart disease, aortic regurgitation, systemic hypertension, renal artery stenosis, cerebrovascular disease, and visual disturbance.[12]

References

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