HLA-B51

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Template:Short descriptionTemplate:Further2

3D representation of HLA-B*5101 (blue) displaying HIV immunodominant epitope KM2 (green) PDB: 1e28
B*5101-β2M with bound peptide Template:PDB2
major histocompatibility complex (human), class I, B51
Alleles B*5101, 5102, 5103, . . .
Structure (See HLA-B) Available
3D structures
EBI-HLA B*5101 Template:PDB2, Template:PDB2

HLA-B51 (B51) is an HLA-B serotype. The serotype identifies the more common HLA-B*51 gene products.[1]

B51 is a split antigen of the broad antigen B5, and is a sister serotype of B52.[2] There are many alleles within the B*51 allele group. B51 is associated with several diseases, including Behçet's disease.

Serotype

Serotypes B51, B5, B52, and B53 recognition of some HLA B*51 allele-group gene products[3]
B*51 B51 B5 B52 B53 Sample
allele % % % % size (N)
Template:Asterisk5101 96 2 1 1899
Template:Asterisk5102 73 3 6 11 218
Template:Asterisk5104 83 17 6
Template:Asterisk5105 48 16 24 25
Template:Asterisk5106 64 7 12 42
Template:Asterisk5107 78 9 68
Template:Asterisk5108 77 3 154
Template:Asterisk5109 86 43
B*Template:Asterisk5102 also reacts to B5102 - 3%, *Template:Asterisk5103 with B5103
Alleles link-out to IMGT/HLA Databease at EBI

Alleles

There are 71 alleles, 57 amino acid sequence variants in B51 of which 4 are nulls. Of these only 9 are frequent enough to have been reliably serotyped. B*5101 is the most common, but others have a large regional abundance.

HLA B*5101 frequencies
freq
ref. Population (%)
[4] Bulgaria 20.9
[4] Georgia Tbilisi Georgians 15.7
[4] India Tamil Nadu Nadar 15.6
[4] China North Han 14.8
[4] Georgia Tbilisi Kurds 12.1
[4] India Andhra Pradesh Golla 12.0
[4] China Qinghai Hui 11.4
[4] India New Delhi 9.8
[4] Madeira 9.7
[4] South Africa Natal Tamil 9.2
[4] USA Hawaii Okinawa 8.7
[4] Cape Verde Northwestern Islands 8.1
[4] Cape Verde Southeastern Islands 7.3
[4] India Mumbai Marathas 6.8
[4] Russia Tuva pop 2 6.1
[4] Israel Arab Druse 6.0
[4] China Inner Mongolia 5.9
[4] Czech Republic 5.7
[4] Finland 5.6
[4] Iran Baloch 8.1
[4] Brazil 5.1
[4] Mexico Guadalajara Mestizos 4.9
[4] New Mexico Canoncito Navajo 4.9
[4] China South Han 4.6
[4] India North Hindus 3.8
[4] Thailand 3.1
[4] Ivory Coast Akan Adiopodoume 2.3
[4] Singapore Chinese Han 2.3
[4] Singapore Javanese Indonesians 2.0
[4] Taiwan Saisiat 2.0
[4] Kenya 1.7
[4] Cameroon Yaounde 1.6
[4] Senegal Niokholo Mandenka 1.6
[4] Guinea Bissau 1.5
[4] USA Arizona Pima 1.1
[4] Venezuela Perja Mountain Bari 1.1
[4] Taiwan Pazeh 0.9
[4] China Guangdong Meizhou Han 0.5
[4] Israel Ashk. & Non Ashk. Jews 0.5
[4] Singapore Thai 3.0
[4] Iran Baloch 1.0
[4] USA Asian 1.0

Disease associations

By serotype

Bw51 was associated with Behçet's disease,[5] in endemic (versus epidemic) mucocutaneous lymph node syndrome,[6] susceptibility to the virus that causes German measles infection.[7]

HLA B*5102 frequencies
freq
ref. Population (%)
[4] Mexico Sonora Seri 1.5
[4] Thailand 1.4
[4] Singapore Chinese 1.3
[4] Hong Kong Chinese 1.0
[4] USA Natives 0.8
[4] Mexico Zaptotec Oaxaca 0.7
[4] South Korea pop 3 0.6
[4] Shijiazhuang Tianjian Han 0.5
[4] China Guangxi Maonan 0.5
[4] Japan (5) 0.4
[4] USA Asian 0.4
[4] USA Hispanic 0.4
[4] USA African America 0.2

In Behçet's disease

Behçet's disease is an inflammation of the wall of blood vessels that can involve the eyes, skin, and the rest of the body.[8] Several alleles of B51 (B*5101, B*5108, B*5105, and B*5104) are found in disease, and linkage to markers, D6S285, in the HLA locus was strong (P<0.005).[9] Homozygotes of B51 showed considerably high risk for disease indicating a possible gene-dose effect. B51 is capable of distinguishing several varieties of disease. HLA-B51 is found more frequently in disease that has an eye involvement.[10] However it is less common in some regions when there is increased neurological involvement.[11] The MICA*009 allele has been found to also associated with ABD when B51 is also present,[12] IL-8 and other cytokines may also be involved.[13][14] Sister chromatid exchange has also been observed more frequently in B51(+) ABD.[15]

However, B51 tends not to be found in ABD when a certain SUMO4 gene variant is involved,[16] and symptoms appear to be milder when HLA-B27 is present.[17]

References

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