HLA-A66
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HLA-A66 (A66) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α66 subset of HLA-A α-chains. For A66, the alpha "A" chain are encoded by the HLA-A<templatestyles src="Template:Color/styles.css" />*66 allele group and the β-chain are encoded by B2M locus.[1] A66 and A<templatestyles src="Template:Color/styles.css" />*66 are almost synonymous in meaning. A66 is a split antigen of the broad antigen serotype A10. A66 is a sister serotype of A25, A26, A34, and A43. Script error: No such module "labelled list hatnote". A66 is more common in Africa and Southwest Europe. A66 (A*6601) is believed to have been formed by a single gene conversion between another HLA-A and the A*2601 allele.[2].
Serotype
| A*66 | A66 | A<templatestyles src="Template:Color/styles.css" />10 | A<templatestyles src="Template:Color/styles.css" />26 | A<templatestyles src="Template:Color/styles.css" />34 | Sample |
| allele | % | % | % | % | size (N) |
| *6601 | 20 | <templatestyles src="Template:Color/styles.css" />10 | <templatestyles src="Template:Color/styles.css" />61 | <templatestyles src="Template:Color/styles.css" />8 | 799 |
| *6602 | 38 | <templatestyles src="Template:Color/styles.css" />10 | <templatestyles src="Template:Color/styles.css" />4 | <templatestyles src="Template:Color/styles.css" />27 | 205 |
| *6603 | 32 | <templatestyles src="Template:Color/styles.css" />7 | <templatestyles src="Template:Color/styles.css" />7 | <templatestyles src="Template:Color/styles.css" />18 | 28 |
A66 serotyping is poor. A*6601 is also sometimes recognized by A25, and A*6602 is often recognized by A74.
A*6601 Frequencies
| freq | ||
| ref. | Population | (%) |
| [4] | Cameroon Sawa | 7.7 |
| [4] | Kenya Luo | 6.8 |
| [4] | Cameroon Sawa | 7.7 |
| [4] | Cameroon Bakola Pygmy | 5.8 |
| [4] | Cameroon Baka Pygmy | 5.0 |
| [4] | Kenya Nandi | 5.0 |
| [4] | Zimbabwe Harare Shona | 0.2 |
| [4] | Cameroon Baka Pygmy | 5.0 |
| [4] | Cameroon Beti | 4.6 |
| [4] | Cameroon Bamileke | 4.5 |
| [4] | India West Bhils | 4.0 |
| [4] | Zimbabwe Harere Shona | 3.8 |
| [4] | Uganda Kampala | 3.8 |
| [4] | India Mumbai Marathas | 2.5 |
| [4] | Cape Verde Northwestern | 2.5 |
| [4] | Czech republic | 2.4 |
| [4] | Morocco Nador Metalsa | 2.1 |
| [4] | Central Portugal | 2.0 |
| [4] | India West Parsis | 2.0 |
| [4] | South African Natal Zulu | 2.0 |
| [4] | Kenya | 1.7 |
| [4] | Tunisia Tunis | 1.7 |
| [4] | Guinea Bissau | 1.5 |
| [4] | Georgia Tbilisi | 1.4 |
| [4] | Zambia Lusaka | 1.2 |
| [4] | Italy Bergamo | 1.1 |
| [4] | Pakistan Karachi Parsi | 1.1 |
| [4] | Oman | 0.8 |
| [4] | Sudanese | 0.8 |
| [4] | Belgium | 0.5 |
| [4] | Southeast France | 0.4 |
| [4] | Mongolia Buriat | 0.4 |
| [4] | Wales | 0.2 |
| freq | ||
| ref. | Population | (%) |
| [4] | South African Natal Zulu | 1.5 |
| [4] | Cameroon Yaounde | 1.1 |
| [4] | Cameroon Bamileke | 0.6 |
| [4] | Senegal Niokholo Mandenka | 0.5 |
| [4] | Kenya Nandi | 0.4 |
| [4] | Zimbabwe Harare Shona | 0.2 |
| [4] | Wales | 0.03 |
| HLA A*6603 frequencies | ||
| freq | ||
| ref. | Population | (%) |
| [4] | Cameroon Pygmy Baka | 10.0 |
| [4] | Cameroon Bakola Pygmy | 9.0 |
| [4] | Cameroon Sawa | 7.7 |
| [4] | CAR Mbenzele Pygmy | 2.8 |
| [4] | Zimbabwe Harare Shona | 0.2 |
References
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- ↑ Allele Query Form IMGT/HLA - European Bioinformatics Institute
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