GNA13

Template:Short description Template:Cs1 config Template:Infobox gene Guanine nucleotide-binding protein subunit alpha-13 is a protein that in humans is encoded by the GNA13 gene.^[1]^[2]

Interactions and functions

The GNA13 gene encodes the G₁₃ G protein alpha subunit. Together with GNA12, these two proteins comprise one of the four classes of heterotrimeric G protein alpha subunits.^[3] Heterotrimeric G proteins function in transducing hormone and neurotransmitter signals detected by cell surface G protein-coupled receptors to intracellular signaling pathways to modulate cell functions. G protein alpha subunits bind to guanine nucleotides and function in a regulatory cycle, and are active when bound to GTP but inactive and associated with the G beta-gamma complex when bound to GDP.^[4]^[5]

Active GTP-bound G₁₂ alpha subunit interacts with and activates ARHGEF1,^[6]^[7]^[8] ARHGEF11,^[9]^[10] and ARHGEF12.^[11]^[12] These ARHGEF proteins function as guanine nucleotide exchange factors for the Rho small GTPases to regulate the actin cytoskeleton.^[13]

GNA13 has been shown to interact with AKAP3,^[14] RIC8A,^[15]^[16] and Radixin.^[17]

Recurrent mutations in this gene have been associated to cases of diffuse large B-cell lymphoma.^[18]^[19]

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.