GNA12
Template:Short description Template:Cs1 config Template:Infobox gene Guanine nucleotide-binding protein subunit alpha-12 is a protein that in humans is encoded by the GNA12 gene.[1][2][3]
Interactions and functions
The GNA12 gene encodes the G12 G protein alpha subunit. Together with GNA13, these two proteins comprise one of the four classes of heterotrimeric G protein alpha subunits.[4] Heterotrimeric G proteins function in transducing hormone and neurotransmitter signals detected by cell surface G protein-coupled receptors to intracellular signaling pathways to modulate cell functions. G protein alpha subunits bind to guanine nucleotides and function in a regulatory cycle, and are active when bound to GTP but inactive and associated with the G beta-gamma complex when bound to GDP.[5][6]
Active GTP-bound G12 alpha subunit interacts with and activates ARHGEF1,[7] ARHGEF11,[8][9] and ARHGEF12.[10][11] These ARHGEF proteins function as guanine nucleotide exchange factors for the Rho small GTPases to regulate the actin cytoskeleton.[12]
GNA12 also interacts with PPP5C,[13] HSP90,[14] Resistance to inhibitors of cholinesterase-8A (Ric-8A)[15] and TEC.[11]
See also
References
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External links
- Template:Replace at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Template:PDBe-KB2
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