Eva Nogales
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Eva Nogales (born May 16, 1965)Script error: No such module "Unsubst". is a Spanish-American biophysicist at the Lawrence Berkeley National Laboratory and a professor at the University of California, Berkeley, where she served as head of the Division of Biochemistry, Biophysics and Structural Biology of the Department of Molecular and Cell Biology (2015–2020). She is a Howard Hughes Medical Institute investigator.
Nogales is a pioneer in using electron microscopy for the structural and functional characterization of macromolecular complexes. She used electron crystallography to obtain the first structure of tubulin and identify the binding site of the important anti-cancer drug taxol. She is a leader in combining cryo-EM, computational image analysis and biochemical assays to gain insights into function and regulation of biological complexes and molecular machines.[1] Her work has uncovered aspects of cellular function that are relevant to the treatment of cancer and other diseases.[2]
Early life and education
Eva Nogales obtained her BS degree in physics from the Autonomous University of Madrid in 1988.[3] She later earned her PhD from the University of Keele in 1992 while working at the Synchrotron Radiation Source under the supervision of Joan Bordas.[3]
Career
During her post-doctoral work in the laboratory of Ken Downing at the Lawrence Berkeley National Laboratory, Eva Nogales was the first to determine the atomic structure of tubulin and the location of the taxol-binding site by electron crystallography.[4][5][6] She became an assistant professor in the Department of Molecular and Cell Biology at the University of California, Berkeley in 1998. In 2000 she became an investigator in the Howard Hughes Medical Institute. As cryo-EM techniques became more powerful,[7] she became a leader in applying cryo-EM to the study of microtubule structure and function[8] and other large macromolecular assemblies such as eukaryotic transcription and translation initiation complexes,[9][10] the polycomb complex PRC2, and telomerase.[11]
Selected publications
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Awards
- 2000: investigator, Howard Hughes Medical Institute
- 2005: Early Career Life Scientist Award, American Society for Cell Biology[12]
- 2006: Chabot Science Award for Excellence
- 2015: Dorothy Crowfoot Hodgkin Award, Protein Society[13]
- 2015: Elected as a member of the US National Academy of Sciences[14]
- 2016: Elected to the American Academy of Arts and Sciences[15]
- 2018: Women in Cell Biology Award (Senior), American Society for Cell Biology[16]
- 2019: Grimwade Medal for Biochemistry.[17]
- 2021: AAAS Fellows Award.[18]
- 2023: Shaw Prize in Life Sciences.[19]
- 2025: Foreign Member of the Royal Society.[20]
Personal life
Nogales is married to Howard Padmore and they have two children.[21]
References
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- ↑ a b Script error: No such module "citation/CS1".
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- ↑ Nogales, E., Wolf, S. G. and Downing, K. H. (1998.) Structure of the ab tubulin dimer by electron crystallography. Nature, 391, 199-203.
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- ↑ Michael A. Cianfrocco, George A. Kassavetis, Patricia Grob, Jie Fang, Tamar Juven-Gershon, James T. Kadonaga, Eva Nogales (2013.) Human TFIID Binds to Core Promoter DNA in a Reorganized Structural State. Cell, 152(1):120–131.
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- ↑ Shaw Prize 2023
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External links
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- Pages with script errors
- Howard Hughes Medical Investigators
- Living people
- Molecular biologists
- Spanish biophysicists
- Women biophysicists
- Biophysicists
- Spanish emigrants to the United States
- University of California, Berkeley faculty
- American women biologists
- 21st-century American women scientists
- Members of the United States National Academy of Sciences
- Alumni of Keele University
- Autonomous University of Madrid alumni
- Structural biologists
- 1965 births
- Foreign members of the Royal Society