Etifelmine
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Template:Short description Template:Drugbox
Etifelmine (INN; also known as gilutensin) is a stimulant drug. It was used for the treatment of hypotension (low blood pressure).[1]
Synthesis
The base-catalyzed reaction between benzophenone (1) and butyronitrile (2) gives 2-[hydroxy(diphenyl)methyl]butanenitrile (3).[2][3] Catalytic hydrogenation reduces the nitrile group to a primary amine giving 1,1-diphenyl-2-ethyl-3-aminopropanol (4). The tertiary hydroxyl group is dehydrated by treatment with anhydrous hydrogen chloride gas, completing the synthesis of etifelmine (5).
See also
References
- ↑ Script error: No such module "Citation/CS1".
- ↑ Etifelmine, Thieme
- ↑ Dr Werner Heinrich & Dr Walter Heigel, <templatestyles src="Citation/styles.css"/>Template:Citation/make linkScript error: No such module "Check for unknown parameters". (1962 to Giulini Gmbh Geb).
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