EPS15

Template:Short description Template:Infobox gene Epidermal growth factor receptor substrate 15 is a protein that in humans is encoded by the EPS15 gene.

Function

This gene encodes a protein that is part of the EGFR pathway. The protein is present at clathrin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemias. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

Interactions

EPS15 has been shown to interact with:

• CRK
• EPN1,
• HGS,
• HRB, and
• REPS2.