CRKL
Template:Cs1 config Template:Short description Template:Infobox gene Crk-like protein is a protein that in humans is encoded by the CRKL gene.[1][2]
Function
v-CRK avian sarcoma virus CT10-homolog-like contains one SH2 domain and two SH3 domains. CRKL has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase and plays a role in fibroblast transformation by BCR-ABL. In addition, CRKL has oncogenic potential.[3]
CrkL together with Crk participates in the Reelin signaling cascade downstream of DAB1.[4][5]
Interactions
CRKL has been shown to interact with:
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- Abl gene,[6][7][8]
- BCAR1,[9][10]
- BCR gene,[7][11][12][13]
- CBLB,[14]
- CD117,[15][16]
- CD34,[17]
- Cbl gene,[6][16][18][19][20][21][22][23][24][25]
- Dock2,[26]
- EPOR,[18][27]
- GAB1,[28]
- GAB2,[29]
- INPP5D,[27]
- MAP4K1,[30][31][32]
- MAP4K5,[33]
- NEDD9,[6][10][24][34]
- PIK3R2,[16]
- Paxillin[35][36]
- RAPGEF1,[6][18][28][37][38][39][40]
- RICS,[41]
- STAT5A,[42]
- Syk,[43] and
- WAS.[43]
See also
References
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Further reading
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External links
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