C5a receptor

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The C5a receptor also known as complement component 5a receptor 1 (C5AR1) or CD88 (Cluster of Differentiation 88) is a G protein-coupled receptor for C5a. It functions as a complement receptor.[1] C5a receptor 1 modulates inflammatory responses, obesity, development and cancers.[2][3][4] From a signaling transduction perspective, C5a receptor 1 activation is implicated in β-arrestin2 recruitment via Rab5a,[5] coupling of Gαi proteins,[6] ERK1/2 phosphorylation, [7] calcium mobilization and Rho activation[8] leading to downstream functions, such as secretion of cytokines, chemotaxis, and phagocytosis.

File:C5a-receptor.png
C5a receptor structure and its residues possessing role in ligand binding or signaling.

Cells

The C5a receptor 1 is expressed on:[9]

Agonist and antagonists

Potent and selective agonist and antagonists for C5a receptor 1 have been developed.[10][11][12][13][14][15]

See also

References

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Further reading

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External links

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