Baicalin
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As baicalin is a flavone glycoside, it is a flavonoid. It is the glucuronide of baicalein.
Natural occurrences
Baicalin is found in several species in the genus Scutellaria, including Scutellaria baicalensis,[1] and Scutellaria lateriflora. There are 10 mg/g baicalin in Scutellaria galericulata leaves.[2] It is also present in the bark isolate of the Oroxylum indicum tree.
Medical uses
Baicalin is one of the chemical ingredients of at least two herbal supplements: Shuanghuanglian[1] and Sho-Saiko-To, which is a Chinese classic herbal formula, and listed in Japan as Kampo medicine.Script error: No such module "Unsubst".
Baicalin, along with its aglycone baicalein, is a positive allosteric modulator of the benzodiazepine site and/or a non-benzodiazepine site of the GABAA receptor.[3][4][5] In mice, baicalin produces anxiolytic effects without sedative or myorelaxant effects.[6][7] It is thought that baicalin, along with other flavonoids, may underlie the anxiolytic effects of S. baicalensis and S. lateriflora.[8][9]
Baicalin is a known prolyl endopeptidase inhibitor.[10] It induces apoptosis in pancreatic cancer cells.[11]
References
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- ↑ a b Script error: No such module "Citation/CS1".
- ↑ P.H. and Horhammer, L., Hager's Handbuch der Pharmazeutischen Praxis, Vols. 2-6, Springer-Verlag, Berlin, 1969-1979
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