6-MeO-THH
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6-MeO-THH, also known as 6-methoxy-1,2,3,4-tetrahydroharman, is a β-carboline (or more specifically a pinoline) derivative and a structural isomer of tetrahydroharmine (7-MeO-THH).[1] It is mentioned in Alexander Shulgin's book TiHKAL (Tryptamines I Have Known and Loved), stating that 6-MeO-THH is very similar to the other carbolines.[2] The compound has been isolated from certain plants of the Virola family.Script error: No such module "Unsubst".
Effects
6-MeO-THH is reported to be hallucinogenic similarly to other β-carbolines like harmaline.[1] Limited testing suggests that it possesses mild psychoactive effects at a dose of 1.5Script error: No such module "String".mg/kg orally and is said to be about one-third as potent as 6-methoxyharmalan and three times as potent as harmaline.[1][3]
Pharmacology
Very little is known about the psychoactivity of 6-MeO-THH in humans. Studies in rats have shown it to bind to a number of serotonin 5-HT1 receptors and 5-HT2 receptors, dopamine D2 receptors, benzodiazepine receptors, and imidazoline receptors.[3][4][5]
See also
References
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