ZNF423
Template:Short description Template:Infobox gene Zinc finger protein 423 is a protein that in humans is encoded by the ZNF423 gene.[1][2][3]
The protein encoded by this gene is a nuclear protein that belongs to the family of Kruppel-like C2H2 zinc finger proteins. It functions as a DNA-binding transcription factor by using distinct zinc fingers in different signaling pathways. Thus, it is thought that this gene may have multiple roles in signal transduction during development.[3] Mice lacking the homologous gene Zfp423 have defects in midline brain development, especially in the cerebellum,[4][5][6] as well as defects in olfactory development,[7] and adipogenesis.[8][9] Patients with mutations in ZNF423 have been reported in Joubert Syndrome and nephronophthisis.[10]
Interactions
ZNF423 has been shown to interact with EBF1,[11] PARP1,[12] Notch intracellular domain,[13] retinoic acid receptor,[14] and CEP290.[10]
References
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Further reading
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External links
- Template:Replace at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.