XF-73
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XF-73 (Exeporfinium chloride) is an experimental drug candidate. It is an anti-microbial that works via weakening bacteria cell walls.[1] It is a potential treatment for methicillin-resistant Staphylococcus aureus (MRSA) and possibly Clostridioides difficile. It is being developed by Destiny Pharma Ltd.[2][3][4]
Structurally, it is a dicationic porphyrin.[5]
It has completed a phase I clinical trial for nasal decolonisation of MRSA—being tested against 5 bacterial strains. It seems unlikely to cause MRSA to develop resistance to it.[1][6]
In 2014, a phase 1 clinical trial for nasal administration was run.[7]
As of June 2022[update]Script error: No such module "Check for unknown parameters"., another phase 1 clinical trial (for nasal administration) completed recruiting in 2016 but no results have been posted.[8]
References
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- ↑ a b Script error: No such module "citation/CS1".
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- ↑ Study of the Nasal Decolonisation of Staphylococcus Aureus (SA) and the Safety and Tolerability of XF-73 Nasal Gel in Healthy Subjects
- ↑ Study of the Safety and Local Tolerability of Intranasal Gel Formulations of XF-73
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