Very long chain fatty acid
Template:Short description A very-long-chain fatty acid (VLCFA) is a fatty acid with 22 or more carbons. Their biosynthesis occurs in the endoplasmic reticulum.[1] VLCFA's can represent up to a few percent of the total fatty acid content of a cell.[2]
Unlike most fatty acids, VLCFAs are too long to be metabolized in the mitochondria, in the endoplasmic reticulum (ER) in plants and must be metabolized in peroxisomes.
Certain peroxisomal disorders, such as adrenoleukodystrophy and Zellweger syndrome, can be associated with an accumulation of VLCFAs.[3][4] Enzymes that produce VLCFAs are the targets of herbicides including pyroxasulfone.[5][6]
Major VLCFAs
Some of the more common saturated VLCFAs: lignoceric acid (C24), cerotic acid (C26), montanic acid (C28), melissic acid (C30), lacceroic acid (C32), ghedoic acid (C34), and the odd-chain fatty acid ceroplastic acid (C35). Several monounsaturated VLCFAs are also known: nervonic acid (Δ15-24:1), ximenic acid (Δ17-26:1), and lumequeic acid (Δ21-30:1).[7]
See also
- ACADVL
- SLC27A2
- SLC27A5
- Cerotic acid, the fatty acid associated with adrenoleukodystrophy
References
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- ↑ Jakobsson, Andreas; Westerberg, Rolf; Jacobsson, Anders "Fatty acid elongases in mammals: their regulation and roles in metabolism" Progress in Lipid Research 2006, volume 45, pp. 237-249. Script error: No such module "CS1 identifiers".
- ↑ "Very-long-chain fatty acids from the animal and plant kingdoms" Rezanka, Tomas Progress in Lipid Research 1989, volume 28, pp. 147-87. Script error: No such module "CS1 identifiers".
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Bibliography
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