Vacuolar interface dermatitis

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File:Vacuolar interface dermatitis, annotated.jpg
Vacuolar interface dermatitis, with lymphocytes in the dermis and epidermis (black arrow indicates one), and vacuolization (white arrow) at the dermoepidermal junction.
File:Vacuolar interface dermatitis - high mag.jpg
Micrograph of a vacuolar interface dermatitis with dermal mucin, as may be seen in lupus. H&E stain.

Vacuolar interface dermatitis (VAC, also known as liquefaction degeneration, vacuolar alteration or hydropic degeneration) is a dermatitis with vacuolization at the dermoepidermal junction, with lymphocytic inflammation at the epidermis and dermis.[1]

Causes

Template:Table of causes of vacuolar interface dermatitis An interface dermatitis with vacuolar alteration, not otherwise specified, may be caused by viral exanthems, phototoxic dermatitis, acute radiation dermatitis, erythema dyschromicum perstans, lupus erythematosus and dermatomyositis.[2]

References

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