Tuberous sclerosis complex tumor suppressors
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Script error: No such module "about". Tuberous sclerosis complex (TSC) tumor suppressors form the TSC1-TSC2 molecular complex. Under poor growth conditions the TSC1-TSC2 complex limits cell growth.[1] A key promoter of cell growth, mTORC1, is inhibited by the tuberous sclerosis complex.[1] Insulin activates mTORC1 and causes dissociation of TSC from the surface of lysosomes.[2]
Resistance to ischemia-reperfusion injury by protein restriction is mediated by activation of the tuberous sclerosis complex.[3]