Tropine

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Tropine
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MeSH Tropine
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Appearance White hygroscopic crystalline powder[1][2][3] or plates
Odor Amine-like[2]
Density 1.045 g/cm3 at 25 °C[2]
1.016 g/cm3 at 100 °C
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Solubility Very soluble in water, diethyl ether, ethanol[4]

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Tropine is a derivative of tropane containing a hydroxyl group at the third carbon. It is also called 3-tropanol.[4] It is a poisonous white hygroscopic crystalline powder.[3] It is a heterocyclic alcohol and an amine.[3]

Tropine is a central building block of many chemicals active in the nervous system, including tropane alkaloids. Some of these compounds, such as long-acting muscarinic antagonists are used as medicines because of these effects.[5]

Occurrence

Tropine is a natural product found in the plants of deadly nightshade (Atropa belladonna) and devil's trumpet (Datura stramonium).[1]

Chemistry

Synthesis

It can be prepared by hydrolysis of atropine[6] or other solanaceous alkaloids.[3]

See also

References

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