Thiamine monophosphate
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| MeSH | Thiamine+Monophosphate |
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| Template:Longitem | C12H18N4O4PS+ |
| Molar mass | 345.336 g/mol |
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Thiamine monophosphate, also known as ThMP and TMP, is a phosphate ester of thiamine.[1]
It is an intermediate from the hydrolysis of thiamine diphosphate to free thiamine by alkaline phosphatase.[2][3][4] The conversion of ThMP to thiamine cannot be facilitated by acid hydrolysis.[5] ThMP is also enzymatically synthesized by thiamine-phosphate pyrophosphorylase, which combines thiazole in its monophosphate form and pyrimidine as a pyrophosphate.[6]
The physiological function of ThMP has not been identified.[2]
Physiological presence
In whole human blood, both ThMP and free thiamine are present in lower concentrations as compared to TPP, but they are found in low amounts in plasma.[4] ThMP is the only phosphorylated thiamine derivative found in human cerebral spinal fluid.[4][7]
It occurs naturally in bovine milk.[8]
In rats, approximately 64% of the total thiamine in plasma exists in its the monophosphate form.[9] After injection of ThMP into the femoral vein of rats, it was quickly transported to the cerebral tissue without chemical modification, but the average transport rate was 5-10 times slower than that of thiamine.[10]
References
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