TSPAN4
Template:Short description Template:Infobox gene Tetraspanin-4 is a protein that in humans is encoded by the TSPAN4 gene.[1][2]
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is similar in sequence to its family member CD53 antigen. It is known to complex with integrins and other transmembrane 4 superfamily proteins. Alternatively spliced transcript variants encoding different isoforms have been identified.[2]
Interactions
TSPAN4 has been shown to interact with CD9,[1] ITGA6,[1] CD29,[1] CD49c[1] and CD81.[1]
References
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Further reading
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