TRIB3

Template:Cs1 config Template:Short description Template:Infobox gene Tribbles homolog 3 is a protein that in humans is encoded by the TRIB3 gene.

Function

The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. It is a pseudoenzyme that is thought to be a negative regulator of NF-kappaB, and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein has been reported to negatively regulate the cell survival serine-threonine kinase AKT1. TRIB3 has recently been associated with neuronal signalling, and like TRIB1 and TRIB2, could be considered as a potential allosteric drug target.

Interactions

TRIB3 has been shown to interact with:

• AKT1,
• CSNK2B,
• Fibronectin
• MCM3AP,
• RELA,
• SIAH1, and
• TIAF1.

Further reading

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