TRADD

Template:Cs1 config Template:Short description Template:Infobox gene Tumor necrosis factor receptor type 1-associated DEATH domain protein is a protein that in humans is encoded by the TRADD gene.

TRADD is an adaptor protein.

Function

The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-κB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway.

File:TNF signaling.jpg

Signaling pathway of TNF-R1. Dashed grey lines represent multiple steps

Interactions

TRADD has been shown to interact with:

• FADD,
• Keratin 18
• RIPK1,
• STAT1,
• TNFRSF1A,
• TNFRSF25, and
• TRAF2.

See also

• TRAF
• RIP

External links

• Template:Replace at the U.S. National Library of Medicine Medical Subject Headings (MeSH)