TMPRSS6

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Template:Short description

Template:Infobox gene Transmembrane protease, serine 6 (also known as matriptase-2) is an enzyme that in humans is encoded by the TMPRSS6 gene.[1]

Based on twin studies, mutations in TMPRSS6 gene have a correlation with iron deficiency predisposition.[2]

The protein encoded by this gene is a type II transmembrane serine proteinase that is found attached to the cell surface. The encoded protein may be involved in matrix remodeling processes in the liver.[1]

References

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  2. ↑ An P, Wu Q, Wang H, et al. TMPRSS6, but not TF, TFR2 or BMP2 variants are associated with increased risk of iron-deficiency anemia. Hum Mol Genet. 2012;21(9):2124-2131.

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Further reading

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