TMBIM4
Template:Short description Template:Infobox gene Transmembrane BAX inhibitor motif-containing protein 4 is a protein that in humans is encoded by the TMBIM4 gene.[1][2][3] It is also known as human Golgi anti-apoptotic protein (hGAAP) due to its function and sub-cellular localization.
Function
Human GAAP [4] is a protein present in the Golgi that helps regulate apoptosis, a form of programmed cell death. By regulating the fluxes of Ca+2, an increase of GAAP can help prevent apoptosis.[5][6] GAAP is also involved in promoting cell migration[7] [8] and has been identified as a novel Golgi cation channel.[9] Other GAAPs can be found in all eucaryotes analyzed and in some bacteria. A viral GAAP (vGAAP) can also be found in some strains of vaccinia virus, the live vaccine used to eradicate smallpox.
See also
- Golgi
- Apoptosis
- Ion channel
- Cell migration
References
<templatestyles src="Reflist/styles.css" />
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
- ↑ Script error: No such module "Citation/CS1".
Script error: No such module "Check for unknown parameters".
Further reading
<templatestyles src="Refbegin/styles.css" />
- Script error: No such module "Citation/CS1".
- Script error: No such module "Citation/CS1".
- Script error: No such module "Citation/CS1".
- Script error: No such module "Citation/CS1".
- Script error: No such module "Citation/CS1".
- Script error: No such module "Citation/CS1".