TFCP2
Template:Short description Template:Infobox gene Alpha-globin transcription factor CP2 is a protein that in humans is encoded by the TFCP2 gene.[1][2]
TFCP2 is also called Late SV40 factor (LSF) and it is induced by well-known oncogene AEG-1.[3] LSF also acts as an oncogene in hepatocellular carcinoma.[4] LSF enhances angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9 (MMP9).[5]
Along with its main oncogene function in hepatocellular carcinoma (HCC), it plays multifaceted role in chemoresistance, epithelial-mesenchymal transition (EMT), allergic response, inflammation and Alzheimer's disease.[4][6] The small molecule FQI1 (factor quinolinone inhibitor 1) prevents LSF from binding with HCC DNA, which results in HCC cell death.[4][6][7]
Interactions
TFCP2 has been shown to interact with APBB1[8] and RNF2.[9]
References
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Further reading
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