Syndecan-2

Template:Short description Template:Infobox gene Syndecan-2 is a protein that in humans is encoded by the SDC2 gene.

Function

The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for the internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types.

Interactions

SDC2 has been shown to interact with:

• CASK,
• Laminin, alpha 3, and
• EZR

Further reading

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