Sulfamide
Template:Short description Template:Chembox
Sulfamide (IUPAC name: sulfuric diamide) is a compound with the chemical formula Template:Chem2 and structure Template:Chem2. Sulfamide is produced by the reaction of sulfuryl chloride with ammonia. Sulfamide was first prepared in 1838 by the French chemist Henri Victor Regnault.[1]
Sulfamide functional group
In organic chemistry, the term sulfamide may also refer to the functional group which consists of at least one organic group attached to a nitrogen atom of sulfamide.
Symmetric sulfamides can be prepared directly from amines, sulfur dioxide gas and an oxidant:[2]
In this example, the reactants are aniline, triethylamine (Template:Chem2, Et = ethyl group), and iodine. Sulfur dioxide is believed to be activated through a series of intermediates: Template:Chem2, Template:Chem2 and Template:Chem2.
The sulfamide functional group is an increasingly common structural feature used in medicinal chemistry.[3]
See also
References
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- ↑ Regnault, Victor (1838) "Sur l'acide chlorosulfurique et la sulfamide" (On sulfuryl chloride and sulfamide), Script error: No such module "Lang"., series 2, 69 : 170-184; see especially "Script error: No such module "Lang"." (Action of dry ammonia gas on liquid sulfuryl chloride), pages 176-180.
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