Stibophen
Template:Short description Template:Drugbox
Stibophen is an anthelmintic originally developed by Bayer that is used as a treatment for schistosomiasis[1] by intramuscular injection. It is classified as a trivalent antimony compound. Brand names include Fouadin/Fuadin (named in honor of Fuad I of Egypt, who had enthusiastically supported its research and development).[2][3]
Mechanism of action
Stibophen inhibits the enzyme phosphofructokinase, which the worms need for glycolysis,[4] at least partly by binding to the sulfhydryl (–SH) group of the enzyme.[5] Inhibiting glycolysis paralyzes the worms, which lose their hold on the wall of mesenteric veins and undergo hepatic shift, die, and are phagocytosed by liver cells.Script error: No such module "Unsubst".
References
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