snRNP70

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Template:Short description

Template:Infobox gene snRNP70 also known as U1 small nuclear ribonucleoprotein 70 kDa is a protein[1] that in humans is encoded by the SNRNP70 gene.[2][3] snRNP70 is a small nuclear ribonucleoprotein that associates with U1 spliceosomal RNA, forming the U1snRNP a core component of the spliceosome. The U1-70K protein and other components of the spliceosome complex form detergent-insoluble aggregates in both sporadic and familial human cases of Alzheimer's disease.[4][5] U1-70K co-localizes with Tau in neurofibrillary tangles in Alzheimer's disease.

Interactions

snRNP70 has been shown to interact with ASF/SF2,[6][7] SRPK1,[8][9] and ZRANB2.[10]

Role in autoimmunity

Antibodies towards snRNP70 are associated with mixed connective tissue disease.[11]

References

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Further reading

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Template:Ribonucleoproteins

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